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KD-Validated Anti-Aquaporin 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P29972 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 1850 |
| Calculated MW | Predicted, 29 kDa ; Observed, 28 kDa |
| Gene Name | AQP1 |
| Aliases | AQP1; Aquaporin 1 (Colton Blood Group); CHIP28; Aquaporin 1 (Channel-Forming Integral Protein, 28kDa, CO Blood Group); Water Channel Protein For Red Blood Cells And Kidney Proximal Tubule; Urine Water Channel; Aquaporin-CHIP; Aquaporin-1; CO; Aquaporin 1 (Channel-Forming Integral Protein, 28kDa); Channel-Like Integral Membrane Protein, 28-KDa; Aquaporin 1, Colton Blood Group Antigen; Colton Blood Group Antigen; Bloodgroup CO Protein; Colton Blood Group; Aquaporin 1; AQP-CHIP; AQP-1 |
| Immunogen | A synthesized peptide derived from human AQP1 |
| Gene ID | 358 |
|---|---|
| Other Names | Aquaporin-1, AQP-1, Aquaporin-CHIP, Channel-like integral membrane protein of 28 kDa, Urine water channel, AQP1 (HGNC:633) |
| Name | AQP1 (HGNC:633) |
|---|---|
| Function | Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2334
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